My gut answer is “The Wizard of Oz is a fucking masterpiece and 2001: A Space Odyssey is fucking dull.”
The honest answer is that Wizard is due for a rewatch in light of HAA! and I’ve only seen 2001 once and it was about ten years ago (in fact, both are now currently on why watchlist for HBO Max, which I got last week).
Even if I end up liking 2001 next time, though, it’s extremely unlikely I’d rank it anywhere near Wizard in terms of quality, soul, or legacy.